In "Your Sister's Sister," set against the damp foliage of the Pacific Northwest, "Humpday" star Mark Duplass plays Jack, still reeling from his brother's death a year earlier. His close friend Iris (Emily Blunt), who happens to also be the ex of Jack's brother, ships him off to her family's remote vacation home so he can be alone to get himself back together.Jack unexpectedly finds Iris' sister Hannah (Rosemarie DeWitt) there for similar purposes, and the two quickly get to know each other over an evening of tequila. When Iris arrives unannounced the next morning, it sets off a chain reaction of revelations and shifting dynamics.
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